2. Signaling Pathways
  3. Immunology/Inflammation
  4. Fc Receptor (FcR)

Fc Receptor (FcR) 

Fc Receptor

Fc Receptors (FcR) are a class of cell surface receptors that can recognize and bind to the Fc region of immunoglobulins, playing an important role in processes such as the immune response and immune regulation. According to the types of immunoglobulins they recognize, FcR can be classified into FcγR, FcεR, FcαR, etc. According to their functional characteristics, they can be divided into activating FcR and inhibitory FcR. FcR mediate the phagocytosis of immune cells, prompting phagocytes to eliminate antigenic foreign substances such as pathogens. FcR also participate in ADCC, which activates NK cells and other cells to kill target cells, affecting the immune response. In addition, FcR can clear immune complexes and prevent them from depositing in tissues and triggering inflammation. Abnormal functions or dysregulated expressions of FcR can lead to autoimmune diseases and allergic diseases. In tumors, FcR are involved in both the immune escape of tumor cells and can serve as targets for immunotherapy[1][2].

Fc Receptor (FcR) 相关产品 (11):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P99037
    Nipocalimab

    尼卡利单抗

    		99.90%
    Nipocalimab (M281) 是一种全人源的重组非糖基化 IgG1 单克隆抗体。Nipocalimab 是一种人去糖基化 IgG1 抗 FcRn 单克隆抗体，在体内 pH 6.0 和胞外 pH 7.6 下均以皮摩尔亲和力与Fc 受体 (FcRn) 结合。
    Nipocalimab
  • HY-P99979
    Rat IgG1 kappa, Isotype Control 99.90%
    Rat IgG1 kappa, Isotype Control是一种鼠源单克隆抗体，是 Rat IgG1κ 抗体的同型对照。
    Rat IgG1 kappa, Isotype Control
  • HY-P99529
    Valziflocept

    维多组单抗

    		99.00%
    Valziflocept (BAX1810; TAK-752) 是一种重组可溶性人 FcγRIIb 受体，可以靶向 Fc 和 FcγR。FcγRs 可以结合并中和致病的 IgG，从而形成一种“诱饵”或“清道夫”受体，能够减轻自身免疫性疾病的严重程度。Valziflocept 可用于系统性红斑狼疮（SLE）等自身免疫性疾病研究。
    Valziflocept
  • HY-P990676
    VIB-9600 Inhibitor 99.41%
    VIB-9600 是 CHO 表达的人源抗体，靶向 FcgR2a/CD32a。VIB-9600 带有 huIgG1 型重链和 huκ 型轻链，其预测的分子量 (MW) 为 150 kDa。VIB-9600 的同型对照可参考 Human IgG1 kappa, Isotype Control (HY-P99001)。
    VIB-9600
  • HY-P991074
    GMA-161 Inhibitor
    GMA-161 是一种人源化 IgG1 抗体，靶向 Fcγ 受体 III (CD16)。GMA-161 具有研究自身免疫性疾病的潜力。GMA-161 的同型对照可以参考人 Human IgG1 kappa, Isotype Control (HY-P99001)。
    GMA-161
  • HY-P991086
    MGD010 Inhibitor
    MGD010 是一种双特异性 CD32B (FcγRIIb) 和 CD79B 抗体。MGD010 通过 CD32B (FcγRIIb) 与 BCR 成分 CD79B 同时共连接来传递负信号，从而抑制激活的 B 细胞。MGD010 具有研究自身免疫性疾病的潜力。
    MGD010
  • HY-P990244
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) Inhibitor
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) 是小鼠来源的、抗大鼠 FcRn heavy chain heterodimers 的 IgG1 抗体抑制剂。
    Anti-Rat FcRn heavy chain heterodimers Antibody (2G3)
  • HY-145775
    hIgG-hFc receptor-IN-1 Inhibitor
    hIgG–hFc receptor-IN-1 (comp 66) 是人免疫球蛋白G -人新生儿Fc受体 (hIgG-hFcRn)蛋白-蛋白相互作用抑制剂，其 IC50 值为 2 μM。
    hIgG-hFc receptor-IN-1
  • HY-P990413
    Anti-Fc gamma R1 Antibody Inhibitor
    Anti-Fc gamma R1 Antibody 是 CHO 表达的人源抗体，靶向 Fc gamma R1。Anti-Fc gamma R1 Antibody 带有 huIgG1 型重链和 huκ 型轻链，其预测的分子量 (MW) 为 150 kDa。Anti-Fc gamma R1 Antibody 的同型对照可参考 Human IgG1 kappa, Isotype Control (HY-P99001)。
    Anti-Fc gamma R1 Antibody
  • HY-P99996
    Human IgG1 (D265A) kappa, Isotype Control 99.6%
    Human IgG1 (D265A) kappa, Isotype Control是一种人-鼠嵌合型抗体，是Human IgG1 (D265A)κ 抗体的同型对照。
    Human IgG1 (D265A) kappa, Isotype Control
  • HY-158316
    BTL-MK Inhibitor
    BTL-MK (Compound 19) 是口服有效的抗过敏剂，通过与抑制性受体 FcγRIIB 结合，抑制肥大细胞脱粒，IC50 为 6.7 μM。BTL-MK BTL-MK 可以改善人肝微粒体的代谢稳定性。BTL-MK 可改善 Ovalbumins (HY-W250978) 诱导的小鼠食物过敏反应。BTL-MK 具有良好的药代动力学特征。
    BTL-MK
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